NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a common side effect shared by the INSTI class of HIV medications?

Diarrhea
Hypersensitivity reactions
Increased lipid abnormalities
Proteinuria

The correct answer is: Diarrhea

One common side effect shared by the INSTI (integrase strand transfer inhibitor) class of HIV medications is diarrhea. This gastrointestinal side effect is often seen with the use of drugs in this class, such as dolutegravir, bictegravir, and raltegravir. Diarrhea is a frequent adverse reaction reported by patients taking INSTI medications and can range from mild to severe. Other side effects, such as hypersensitivity reactions, increased lipid abnormalities, and proteinuria, are not typically associated with the INSTI class of HIV medications.