NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which platinum-based compound is associated with the highest incidence of nephrotoxicity?

Cisplatin
Carboplatin
Oxaliplatin
Docetaxel

The correct answer is: Cisplatin

Cisplatin is associated with the highest incidence of nephrotoxicity among the platinum-based compounds listed. Nephrotoxicity is a well-known side effect of cisplatin, which can lead to kidney damage and impaired kidney function. It is important for healthcare providers to monitor renal function closely in patients receiving cisplatin to prevent or manage nephrotoxicity effectively. Carboplatin, Oxaliplatin, and Docetaxel are not primarily known for causing nephrotoxicity as a prominent side effect. While these agents may have other side effects, their association with significant nephrotoxicity is much less compared to cisplatin.