NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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A contraindication for Deutetrabenazine is:

Renal impairment
Hepatic impairment
Cardiac arrhythmia
Diabetes

The correct answer is: Hepatic impairment

Deutetrabenazine is a medication used to treat chorea associated with Huntington's disease. One of the key considerations when prescribing Deutetrabenazine is its metabolism, primarily in the liver. Therefore, patients with hepatic impairment may have difficulties in metabolizing the drug properly, leading to potential toxicity and adverse effects. This is why hepatic impairment is a contraindication for Deutetrabenazine. None of the other options (renal impairment, cardiac arrhythmia, diabetes) are specific contraindications for Deutetrabenazine based on its mechanism of action and metabolism.