NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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A contraindication for Lurasidone (Latuda) is:

  1. Use with strong CYP2D6 inducers

  2. Use with alcohol

  3. Use with strong CYP3A4 inducers/inhibitors

  4. Use in patients with diabetes

The correct answer is: Use with strong CYP3A4 inducers/inhibitors

Lurasidone (Latuda) is a medication used to treat certain mental/mood disorders. A contraindication is a specific situation in which a medication should not be used because it may cause harm to the patient. In this case, the contraindication for Lurasidone is the use of strong CYP3A4 inducers or inhibitors. This means that medications or substances that affect the enzyme CYP3A4 in the body can interact with Lurasidone and cause harmful effects. Option A (use with strong CYP2D6 inducers) is incorrect because CYP2D6 is a different enzyme and has no known interaction with Lurasidone. Option B (use with alcohol) is incorrect because while it may not be recommended to consume alcohol while taking Lurasidone, it is not a contraindication. Option D (use in patients with diabetes) is incorrect because Lurasidone does not interact with diabetes medications and can still be used safely in patients with diabetes. Overall, it is crucial for healthcare providers to be aware of contraindications for medications and potential drug interactions to ensure the safety and effectiveness of treatment. Patients should always inform their healthcare