NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Alternative treatment for late latent or tertiary syphilis if allergic to penicillin?

doxy x28 days
azithromycin x1
amoxicillin x7 days
metronidazole

The correct answer is: doxy x28 days

For the treatment of late latent or tertiary syphilis in patients allergic to penicillin, the recommended alternative is doxycycline for 28 days. Doxycycline is a tetracycline antibiotic that has shown effectiveness in treating syphilis in patients who cannot tolerate penicillin. Azithromycin can be used in some cases, but the standard treatment for penicillin-allergic patients is doxycycline. Amoxicillin is a penicillin antibiotic and would not be suitable for patients allergic to penicillin. Metronidazole is an antibiotic commonly used to treat infections like bacterial vaginosis, trichomoniasis, and certain anaerobic bacterial infections, but it is not recommended for treating syphilis.