NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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How frequently must media-fill tests be conducted for high-risk compounding?

Annually
Semi-annually
Quarterly
Every two years

The correct answer is: Semi-annually

Media-fill tests are conducted to ensure proper aseptic technique is being used in high-risk compounding. These tests involve filling a container with media, incubating it, and then examining it for microbial growth. Since maintaining a high degree of sterility is crucial in high-risk compounding, these tests should be conducted more frequently than annually or every two years. Conducting media-fill tests semi-annually allows for a more timely detection of any potential issues with aseptic technique. Quarterly testing would also be acceptable, but it may not provide the same level of assurance as conducting tests every six months. However, conducting media-fill tests too frequently could be burdensome and take away from other essential tasks in the pharmacy. Therefore, semi-annual testing strikes a balance between ensuring proper aseptic technique and practicality.