NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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How is peripheral neuropathy managed when caused by vincristine?

  1. Ensure adequate hydration

  2. Limit dose to 2mg/dose

  3. Stop therapy and administer steroids

  4. Monitor LVEF

The correct answer is: Limit dose to 2mg/dose

Vincristine is a type of chemotherapy medication that can cause nerve damage, known as peripheral neuropathy. When managing this side effect, it is important to limit the dose of vincristine to 2mg per dose. This is because higher doses of the medication can increase the risk of developing or worsening peripheral neuropathy. While ensuring adequate hydration, stopping therapy, and monitoring LVEF may be important for other aspects of the patient's overall health, these options are not specifically targeted towards managing vincristine-induced peripheral neuropathy. Therefore, they are not the most appropriate solutions in this situation.

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