NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What does Dornase alfa (pulmozyme) do?

  1. Increases antibiotic absorption

  2. Degrades extracellular DNA in lungs

  3. Prevents bacterial resistance

  4. Improves pancreas function

The correct answer is: Degrades extracellular DNA in lungs

Dornase alfa (pulmozyme) is an enzyme that works by degrading extracellular DNA in the lungs. This action helps to reduce the viscosity of mucus in patients with cystic fibrosis, making it easier for them to clear their airways. Therefore, the correct answer is B. Option A is incorrect because Dornase alfa does not have a direct effect on antibiotic absorption. Option C is also incorrect as it does not specifically prevent bacterial resistance. Option D is incorrect as Dornase alfa does not improve pancreas function; it is primarily used for pulmonary issues in cystic fibrosis patients.

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