NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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What drugs are used to manage Fluorouracil toxicity?

Uridine triacetate
Dexrazoxane
Amifostine
Atropine

The correct answer is: Uridine triacetate

Uridine triacetate is used to manage Fluorouracil toxicity by competing with 5-fluorouracil for incorporation into RNA. Uridine triacetate can help mitigate the toxic effects of Fluorouracil by reducing the incorporation of Fluorouracil into RNA, ultimately decreasing its cytotoxic effects. Option B, Dexrazoxane, is used for anthracycline-induced cardiotoxicity, not specifically for managing Fluorouracil toxicity. Option C, Amifostine, is a cytoprotective agent used to reduce the risk of xerostomia (dry mouth) caused by radiation therapy to the head and neck, not for managing Fluorouracil toxicity. Option D, Atropine, is primarily used to treat muscarinic symptoms caused by cholinesterase inhibitors or organophosphate poisoning, not specifically for managing Fluorouracil toxicity.