NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a disadvantage of using Quinupristin/Dalfopristin?

Not well tolerated
High cost
Frequent dosing
No gram-positive activity

The correct answer is: Not well tolerated

One of the main disadvantages of using Quinupristin/Dalfopristin is that it is not well tolerated. This means that a significant number of patients may experience side effects or adverse reactions when taking this medication. Some of the more common side effects include nausea, vomiting, diarrhea, and pain at the injection site. These side effects can limit the effectiveness and compliance of the treatment. This is compared to other antibiotics which may have a better tolerability profile. The other options, while they may also be true, are not the primary disadvantage of Quinupristin/Dalfopristin. High cost and frequent dosing may be minor drawbacks, while no gram-positive activity is a false statement as this medication is specifically used to treat gram-positive infections.