NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What is a major adverse effect of Everolimus (Zortress)?

1. Increased blood pressure

2. Hirsutism

3. Hypokalemia

4. Impaired wound healing

The correct answer is: Impaired wound healing

Everolimus (Zortress) is an immunosuppressant medication commonly prescribed to prevent organ rejection in transplant patients. One of the major adverse effects of this medication is impaired wound healing. This is due to the fact that Everolimus suppresses the body's immune response, making it harder for wounds to heal properly. Option A, increased blood pressure, is also a known side effect of Everolimus. However, this is not considered a major adverse effect as it can typically be managed with medication or lifestyle changes. Option B, hirsutism, is not a known adverse effect of Everolimus. Hirsutism is defined as excessive hair growth on the face and body, and is not associated with this medication. Option C, hypokalemia, is a condition where the body has low levels of potassium. While this can be a potential side effect of Everolimus, it is not considered a major adverse effect as it can be managed with dietary changes or potassium supplements. Overall, the most significant adverse effect of Everolimus is impaired wound healing, making it important for patients to closely monitor and care for any wounds while taking this medication.