NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Disable ads (and more) with a membership for a one time $2.99 payment

Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

Practice this question and more.

What is the action mechanism of first-generation antiandrogens like Bicalutamide?

Increase androgen receptor upregulation
Directly inhibit GnRH receptors
Inhibit testosterone from binding to prostate cancer cells
Decrease testosterone synthesis

The correct answer is: Inhibit testosterone from binding to prostate cancer cells

First-generation antiandrogens, such as Bicalutamide, work by inhibiting testosterone from binding to prostate cancer cells. This mechanism of action is crucial in the treatment of prostate cancer, as prostate cancer cells are stimulated by androgens like testosterone. By blocking the binding of testosterone to these cells, first-generation antiandrogens help to slow down the growth and spread of prostate cancer. The other options are not correct because first-generation antiandrogens do not work by increasing androgen receptor upregulation, directly inhibiting GnRH receptors, or decreasing testosterone synthesis.