NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the antidote for Unfractionated Heparin?

Andexanet alfa (Andexxa)
Protamine
Vitamin K
Praxbind

The correct answer is: Protamine

Protamine is the antidote for Unfractionated Heparin because it binds to heparin and neutralizes its effects. Andexanet alfa is used as an antidote for Factor Xa inhibitors, not heparin. Vitamin K is used as an antidote for warfarin, a different type of blood thinner. Praxbind is used as an antidote for dabigatran, another type of blood thinner. Therefore, protamine is the only option that is specifically used as an antidote for Unfractionated Heparin.