NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the main contraindication for using Dextromethorphan in cough treatment?

  1. Do not use within 14 days of MAO inhibitors

  2. Do not use if allergic to aspirin

  3. Do not use with high blood pressure

  4. Do not use in patients with diabetes

The correct answer is: Do not use within 14 days of MAO inhibitors

Dextromethorphan, an ingredient commonly found in cough medicine, should not be used within 14 days of taking MAO inhibitors. This is because taking these two medications together can cause a potentially dangerous increase in serotonin levels, leading to a condition known as serotonin syndrome. The remaining options, while important considerations for medication use, are not specifically contraindications for Dextromethorphan use in cough treatment. For example, while individuals with high blood pressure should exercise caution when taking cough medicines, this is not a direct contraindication. Similarly, having allergies to aspirin or diabetes does not directly prevent the use of Dextromethorphan for cough treatment.