NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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What is the primary function of pharmacokinetic boosters like ritonavir and cobicistat in ART therapy?

To improve gastrointestinal absorption
To enhance the drug's entry into the cell
To inhibit enzymes and improve the main drug's efficacy
To reduce the toxic side effects of the main drug

The correct answer is: To inhibit enzymes and improve the main drug's efficacy

Pharmacokinetic boosters like ritonavir and cobicistat serve the primary function of inhibiting enzymes responsible for metabolizing the main drug in antiretroviral therapy (ART). By inhibiting these enzymes, they effectively increase the plasma concentrations and half-life of the main drug, leading to improved drug efficacy without requiring a higher dose. This enhancement in drug levels helps achieve therapeutic outcomes by ensuring the main drug remains in the body longer and at higher concentrations to combat the virus.