NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What major side effects are associated with Aminoglycosides?

Tendon inflammation/rupture, peripheral neuropathy
QT prolongation, photosensitivity
Nephrotoxicity, ototoxicity
CNS effects, seizures

The correct answer is: Nephrotoxicity, ototoxicity

Aminoglycosides are a type of antibiotic commonly used to treat bacterial infections. They are known to have some potential side effects, but the most significant ones are nephrotoxicity and ototoxicity. Nephrotoxicity refers to damage to the kidneys and can be serious, as it may lead to acute kidney failure. Ototoxicity, on the other hand, refers to damage to the inner ear and can cause hearing loss or balance problems. These two side effects are important to consider when using aminoglycosides and carefully monitoring their use is necessary to prevent any serious complications. The other options listed, such as tendon inflammation/rupture, QT prolongation, photosensitivity, CNS effects, and seizures, while possible side effects of other medications, are not commonly associated with aminoglycosides. Therefore, they are not the major side effects to be concerned about when taking this type of antibiotic. It is important to always discuss any potential side effects with your healthcare provider before starting any new medication.