NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What monitoring is crucial when combining statins with strong CYP3A4 inhibitors?

  1. Blood pressure

  2. Cholesterol levels

  3. Liver function tests

  4. Electrolyte levels

The correct answer is: Liver function tests

Combining statins with strong CYP3A4 inhibitors can significantly increase the risk of liver damage and toxicity. As a result, monitoring liver function tests is crucial to detect any potential liver damage or toxicity early on. Monitoring blood pressure, cholesterol levels, or electrolyte levels may also be important for overall patient health, but they are not directly related to the potential interaction between statins and strong CYP3A4 inhibitors.

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