NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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When should pre-operative antibiotic prophylaxis be administered for it to be effective?

  1. Within 24 hours of first incision

  2. Within 60 minutes of first incision

  3. Within 120 minutes if using quinolone or vancomycin

  4. Post-operation only

The correct answer is: Within 60 minutes of first incision

Pre-operative antibiotic prophylaxis should be administered within 60 minutes of the first incision to be effective. Administering the antibiotics within this timeframe helps to achieve adequate tissue levels at the time of incision, targeting the most susceptible bacteria. This practice has been shown to significantly reduce the risk of surgical site infections. Option A (within 24 hours of first incision) is not ideal as waiting this long can increase the risk of contamination before the antibiotics take effect. Option C (within 120 minutes if using quinolone or vancomycin) provides a longer window compared to the recommended timeframe of 60 minutes. Option D (post-operation only) does not align with the goal of preventing infections before they occur.