NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which agents are known for crossing-link DNA strands?

Alkylating agents
Vinca alkaloids
Antimetabolites
Topoisomerase II inhibitors

The correct answer is: Alkylating agents

Alkylating agents are known for crossing-linking DNA strands. Alkylating agents work by transferring an alkyl group to nucleophilic targets within the DNA molecule, resulting in the formation of covalent bonds with DNA. This covalent binding leads to DNA cross-linking, which interferes with DNA replication and transcription, ultimately causing cell death. Vinca alkaloids, antimetabolites, and topoisomerase II inhibitors work through different mechanisms and do not involve DNA cross-linking as alkylating agents do.