NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which antimicrobial has added activity against MDR Pseudomonas and MDR GNR?

Cefepime
Ceftazidime/avibactam
Cephalexin (PO)
Ceftriaxone

The correct answer is: Ceftazidime/avibactam

Ceftazidime/avibactam is the correct answer as this antimicrobial is an extended-spectrum beta-lactam/beta-lactamase inhibitor combination. This means that it not only has activity against certain bacteria, but also has added activity against multidrug-resistant Pseudomonas and multidrug-resistant gram-negative rods. Cefepime (A) and ceftriaxone (D) are both cephalosporins, but they do not have the added activity against MDR Pseudomonas and MDR GNR like ceftazidime/avibactam does. Cephalexin (C) is an oral medication and therefore would not have sufficient activity against Pseudomonas and gram-negative rods, which typically require IV antibiotics for adequate treatment. In summary, ceftazidime/avibactam is the best choice for treating MDR Pseudomonas and MDR GNR infections due to its additional activity against these difficult-to-treat bacteria.