NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which Beta-1 and Beta-2 Blocker is noted for its use in portal hypertension?

Propranolol
Atenolol
Esmolol
Metoprolol

The correct answer is: Propranolol

Propranolol is the correct answer for this question. Propranolol is a non-selective beta blocker, blocking both beta-1 and beta-2 receptors. In the context of portal hypertension, propranolol is commonly used due to its ability to decrease portal pressure by reducing splanchnic blood flow and cardiac output. This effect helps to prevent variceal bleeding in patients with portal hypertension. Atenolol and metoprolol are selective beta-1 blockers, meaning they primarily block beta-1 receptors and have minimal effect on beta-2 receptors. They are not typically used for portal hypertension as propranolol's non-selectivity is more advantageous in this specific clinical scenario. Esmolol, on the other hand, is an ultra-short-acting selective beta-1 blocker that is commonly used for acute management of atrial fibrillation or supraventricular tachycardia. It is not the preferred choice for portal hypertension compared to propranolol due to its short duration of action and selective beta-1 blocking properties.