NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

Practice this question and more.

Which compound is mentioned as a CYP-3A4 inhibitor?

St. John's wort
Grapefruit juice
R-warfarin
Apixaban

The correct answer is: Grapefruit juice

Grapefruit juice is mentioned as a CYP-3A4 inhibitor as it can increase the activity of this enzyme, leading to decreased metabolism of certain medications, including those listed in options C and D. Option A, St. John's wort, is known to induce CYP-3A4, which would have the opposite effect. Therefore, this compound is not mentioned as a CYP-3A4 inhibitor. While option D, Apixaban, is metabolized by CYP-3A4, it is not specifically mentioned as a CYP-3A4 inhibitor.