NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug causes severe fluid retention and requires premedication with steroids for 3 days?

  1. Paclitaxel

  2. Docetaxel

  3. Cisplatin

  4. Oxaliplatin

The correct answer is: Docetaxel

Docetaxel is the correct answer because it is known to cause severe fluid retention. Premedication with steroids for 3 days prior to docetaxel administration helps to minimize this side effect. Paclitaxel is associated with peripheral edema, but it does not require premedication with steroids for fluid retention. Cisplatin and oxaliplatin are not typically associated with severe fluid retention requiring premedication with steroids.

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