NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which drug is associated with the toxicity of constipation?

Cisplatin
Vincristine
Bleomycin
Irinotecan

The correct answer is: Vincristine

Vincristine is the correct answer because it is associated with the toxicity of constipation. Vincristine is a vinca alkaloid that acts by binding to tubulin in the mitotic spindle, interrupting cell division. One of the common side effects of vincristine is gastrointestinal toxicity, which can include constipation. The other options (A. Cisplatin, C. Bleomycin, and D. Irinotecan) are not typically associated with constipation as a predominant side effect. Cisplatin is known for causing nephrotoxicity and ototoxicity, Bleomycin is associated with pulmonary toxicity, and Irinotecan is known for causing diarrhea, rather than constipation.