NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which drugs are known for causing Nephrotoxicity?

Irinotecan and Vincristine
Cisplatin and MTX
Bleomycin and Busulfan
Anthracyclines

The correct answer is: Cisplatin and MTX

Explanation Nephrotoxicity refers to the harmful effects that drugs can have on the kidneys. Out of the given options, cisplatin and MTX are most commonly known for causing nephrotoxicity. Irinotecan and Vincristine (option A) and Bleomycin and Busulfan (option C) are drugs more commonly associated with other side effects and do not typically cause nephrotoxicity. Anthracyclines (option D) are not known to cause nephrotoxicity, but they are known for causing cardiac toxicity. Therefore, B is the correct answer as both cisplatin and MTX are known to cause nephrotoxicity.