NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which food should be avoided with CYP3A4 substrates due to risk of increased drug levels and toxicity?

Broccoli
Grapefruit
Bananas
Whole grains

The correct answer is: Grapefruit

Grapefruit should be avoided with CYP3A4 substrates due to the risk of increased drug levels and toxicity. Grapefruit contains compounds that inhibit the CYP3A4 enzyme in the liver, responsible for metabolizing many medications. When this enzyme is inhibited, the drug concentration in the body can increase significantly, leading to potential toxicity. Therefore, it is crucial to avoid grapefruit when taking medications metabolized by CYP3A4 to prevent adverse effects. In contrast, the other options listed (Broccoli, Bananas, and Whole grains) do not have significant interactions with CYP3A4 substrates.