NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

Practice this question and more.

Which medication has the highest COX-2 selectivity?

Celecoxib (Celebrex)
Diclofenac (Voltaren)
Meloxicam (Mobic)
Ibuprofen (Advil)

The correct answer is: Celecoxib (Celebrex)

Celecoxib (Celebrex) has the highest COX-2 selectivity among the options provided. COX-2 inhibitors like celecoxib selectively inhibit the cyclooxygenase-2 enzyme, which is responsible for inflammation and pain, while sparing the cyclooxygenase-1 (COX-1) enzyme that helps maintain the stomach lining and normal platelet function. This selectivity helps reduce the risk of gastrointestinal ulcers and bleeding compared to non-selective NSAIDs like diclofenac, meloxicam, and ibuprofen. Thus, celecoxib is preferred in patients who are at higher risk of gastrointestinal complications.