NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which medication is a moderate inhibitor of CYP2D6, 3A4, PGP?

Dronedarone
Quinidine
Propafenone
Sotalol

The correct answer is: Dronedarone

Dronedarone is a moderate inhibitor of CYP2D6, 3A4, and PGP enzymes. This means that it can slow down the metabolism and clearance of drugs that are metabolized by these enzymes, potentially leading to increased levels of these drugs in the body. Therefore, it is important to monitor drug levels and adjust doses accordingly when taking dronedarone. The other options, quinidine, propafenone, and sotalol, may have some inhibitory effects on these enzymes, but they are not considered to be moderate inhibitors like dronedarone. Thus, they may not have the same significant impact on drug metabolism and clearance.