NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which medications are known to cause nephrotoxicity in the context of immunosuppression?

  1. Tacrolimus and cyclosporine

  2. Steroids and mTOR inhibitors

  3. Belatacept and serolimus

  4. Insulin and metformin

The correct answer is: Tacrolimus and cyclosporine

Tacrolimus and cyclosporine are both immunosuppressive medications commonly used in transplant patients to prevent organ rejection. While they are effective in suppressing the immune system to prevent rejection, they are also known to cause nephrotoxicity, meaning they can damage the kidneys. This is a well-known side effect of these medications and underscores the importance of monitoring renal function in patients taking them. The other options are incorrect because steroids and mTOR inhibitors (Choice B) are not specifically known for causing nephrotoxicity related to immunosuppression. Belatacept and sirolimus (Choice C) are also immunosuppressive agents, but they are not typically associated with nephrotoxicity. Insulin and metformin (Choice D) are medications used to treat diabetes and are not directly related to immunosuppression or nephrotoxicity in the context of organ transplantation.

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