NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which medication's Black Box Warning includes adjusting the dosing interval based on CrCl?

Procainamide
Sotalol
Mexiletine
Dronedarone

The correct answer is: Sotalol

Sotalol is the correct answer because its Black Box Warning includes adjusting the dosing interval based on creatinine clearance (CrCl). Sotalol is a class III antiarrhythmic medication that is used for the treatment of atrial and ventricular arrhythmias. Due to the risk of serious arrhythmias, Sotalol's dosing must be adjusted based on the patient's kidney function, which is usually estimated by the CrCl. It is essential to monitor renal function and adjust the dosing interval accordingly to prevent adverse effects. The other options, Procainamide, Mexiletine, and Dronedarone, do not have Black Box Warnings that specifically mention adjusting dosing intervals based on CrCl. They may have other important warnings and precautions, but not related to renal function as in the case of Sotalol.