NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication's specific instructions include 'do not start if CrCl < 50'?

  1. Complera

  2. Atripla

  3. Both A and B

  4. Neither A nor B

The correct answer is: Both A and B

The correct answer is C, Both A and B. The specific instruction 'do not start if CrCl < 50' is associated with Complera and Atripla. This instruction is important because both Complera and Atripla contain the medication efavirenz, which is primarily metabolized by the liver and is contraindicated in patients with severe hepatic impairment or renal dysfunction (CrCl < 50 mL/min). Therefore, this precaution is included in the prescribing information to ensure patient safety and avoid potential adverse effects.

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