NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

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Which of the following are centrally acting opioid antagonists?

Codeine and Fentanyl
Naloxone and Naltrexone
Morphine and Methadone
Hydromorphone and Oxycodone

The correct answer is: Naloxone and Naltrexone

Centrally acting opioid antagonists work in the central nervous system to block or reverse the effects of opioids. Naloxone and Naltrexone are both centrally acting opioid antagonists. Naloxone is commonly used as an emergency treatment for opioid overdose, as it can quickly reverse the effects of opioids and restore normal respiration. Naltrexone is used for the treatment of opioid and alcohol dependence by reducing cravings and blocking the effects of opioids. The other options listed are not centrally acting opioid antagonists: - Codeine, Fentanyl, Morphine, Methadone, Hydromorphone, and Oxycodone are opioids themselves and do not have antagonist properties; they are agonists that bind to opioid receptors in the central nervous system to produce analgesia or other effects.