NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which of the following is a CYP-3A4 inhibitor?

Rifabutin
Fluconazole
S-warfarin
Efavirenz

The correct answer is: Fluconazole

Fluconazole is a medication used to treat fungal infections that has been known to inhibit the enzyme CYP-3A4, which is responsible for breaking down certain drugs in the body. This can lead to increased levels of other medications in the body, potentially causing harmful side effects. The other options listed, Rifabutin, S-warfarin, and Efavirenz, do not have known inhibitory effects on CYP-3A4. In fact, Rifabutin and Efavirenz are actually inducers of CYP-3A4, meaning they can increase the breakdown of other medications in the body. S-warfarin, a blood thinner, is primarily metabolized by a different enzyme, CYP-2C9. Therefore, it is important to avoid combining medicines that can interact with CYP-3A4, such as fluconazole, with medications that are metabolized by this enzyme.