NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which of the following is a CYP-2C19 substrate?

clopidogrel
fluoxetine
amiodarone
fluoxetine

The correct answer is: clopidogrel

Clopidogrel is the correct answer as it is a known substrate of the CYP-2C19 enzyme. The CYP-2C19 enzyme is responsible for metabolizing a variety of drugs, including clopidogrel. When clopidogrel is administered, it undergoes activation in the liver with the help of CYP-2C19 to its active form, which plays a crucial role in its antiplatelet effects. Amiodarone is primarily metabolized by the CYP-3A4 enzyme, and fluoxetine is mainly metabolized by CYP-2D6. Therefore, these drugs are not substrates of CYP-2C19.