NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Which of the following is not a warning or side effect associated with SGLT2 inhibitors?

1. Increased urination/thirst

2. Weight gain

3. Ketoacidosis

4. Genital mycotic infections

The correct answer is: Weight gain

SGLT2 inhibitors are a class of medications commonly used to treat type 2 diabetes by increasing glucose excretion in the urine. One of the common side effects of SGLT2 inhibitors is increased urination and thirst, as the medication works by increasing glucose excretion in the urine, leading to increased urine production. Ketoacidosis is a serious side effect associated with SGLT2 inhibitors, characterized by the accumulation of ketones in the blood, which can be life-threatening if not treated promptly. Genital mycotic infections are also a known side effect of SGLT2 inhibitors, particularly in females. The reason why option B is the correct answer is that weight gain is not typically associated with SGLT2 inhibitors. In fact, one of the benefits of SGLT2 inhibitors is that they may lead to modest weight loss due to the loss of calories through glucose excretion in the urine. Therefore, weight gain is not a warning or side effect commonly seen with SGLT2 inhibitors, making it the correct answer in this question.