NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Which type of NSAID decreases GI risk?

Non-selective
COX-2 selective
COX-1 selective
Irreversible COX 1/2 inhibitor

The correct answer is: COX-2 selective

NSAIDs are commonly used to reduce pain and inflammation, but they can also have side effects on the gastrointestinal system. One type of NSAID called non-selective inhibitors can block both COX-1 and COX-2 enzymes, leading to an increased risk of GI complications such as stomach ulcers. The option C, COX-1 selective, can also increase the risk of GI side effects. However, COX-2 selective NSAIDs have been specifically designed to target only the COX-2 enzyme, reducing the risk of GI complications. The option D, irreversible COX 1/2 inhibitor, may have a stronger effect on reducing pain but can also cause more severe GI side effects due to its non-selective nature. Therefore, the correct answer is B as COX-2 selective NSAIDs are the best option for decreasing GI risk.