NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Study for the NAPLEX exam with a comprehensive quiz featuring multiple-choice questions and in-depth explanations. Build your pharmacological knowledge and increase your chances of passing the pharmacist licensure examination!

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Who is at higher risk of toxicity with Procainamide due to the conversion to NAPA?

Patients with HF
Slow acetylators
Patients with MI
Fast acetylators

The correct answer is: Slow acetylators

Acetylators are enzymes that metabolize procainamide in the liver. Slow acetylators have a reduced ability to break down procainamide, leading to higher levels of the active metabolite NAPA. This can increase the risk of toxicity in these individuals. Patients with heart failure (HF) or myocardial infarction (MI) may have impaired liver function, but this does not necessarily make them slow acetylators. Fast acetylators, on the other hand, have a higher ability to break down procainamide, reducing the risk of toxicity. Therefore, the correct answer is B slow acetylators.